Periodontal Disease and PreTerm Birth
During normal pregnancy, maternal hormones and
locally acting cytokines play a key role in regulating the onset of labor, cervical
ripening, uterine contraction, and delivery. Maternal infections during pregnancy have
been demonstrated to perturb this normal cytokine and hormone-regulated gestation,
sometimes resulting in preterm labor, preterm premature rupture of membranes, and preterm
low birth weight (PLBW), i.e., < 2,500 g and < 37 weeks of gestation.
Researches done by Offenbacher et al at North
Carolina Univeristy show that periodontitis( gum disease) may be linked to pre-term
pregnancies and low birth weight. More than 60% of mortality among infants without
congenital or anatomical defects is attributable to PLBW. If periodontitis is confirmed as
a risk factor for PLBW, it could provide new opportunities to reduce infant mortality.
In a study on 124 women by Offenbacher,
OReilly and Katz, it was shown that women with periodontitis has an almost eight
fold greater chance of having PLBW infants than mothers without periodontal disease.
Pre-term labor appears to be mediated by the mothers secreted
anti-inflammatory agents such as prostaglandin in response to an infection.
Offenbacher et al found a two fold increase of
prostaglandin E2 in the gum area (crevicular fluid) around the teeth of women with PLBW
infants as compared to women with normal birth weight infants. This suggests a
relationship between prostaglandin concentration in the gum area and inside the amniotic
sac. These data suggest that biochemical measures of maternal periodontal status and oral
microbial burden are associated with current PLBW.
Offenbacher, et al.:Journal Of Dental Education,62(10),852-8,1998
Offenbacher, et al.:Ann Periodontol,3(1),233-50,1998
Gum Disease can increse chances of
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